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What decongestant can I take with BPH? Decongestants, such as pseudoephedrine (Sudafed), are used to treat congestion often associated with a cold. These drugs, which are called vasopressor adrenergics, worsen BPH symptoms because they tighten muscles in the prostate and bladder neck. When these muscles tighten, urine can 't easily leave the bladder.
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