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I am not an old crack but from time to time I suffer from attacks of gout. When it makes me feel really miserable I take allopurinol, but I do not observe any regimen. May be if I would, the attacks would step away. I'll try it next month!
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Neither trial provided data for function, participant global assessment of treatment success or quality of life.
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We have included 11 published trials (seven RCTs and four CCTs) examining the efficacy and safety of allopurinol in the treatment of chronic gout.
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We will avoid a potential unit of analysis issue by making multiple pair-wise comparisons between all possible pairs of intervention groups for trials with multiple treatment groups, or alternatively, by including only the pair with accepted drug dosages ().
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No data for joint pain, function, quality of life, participant global assessment of treatment success, tophus regression or harms were provided.
There was low-quality evidence based on pooled data from three trials (1136 participants) of no between-group difference in the incidence of acute gout attacks when allopurinol up to 300 mg daily was compared with febuxostat 80 mg daily over an eight-week period, during which co-administration of flare prophylaxis with naproxen or colchicine was given in two trials ( ), and up to a 24-week period (six months) in the third trial (), which did not provide flare prophylaxis.
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This is consistent with our results comparing allopurinol with febuxostat 120 and 240 mg for acute gout attacks and our results comparing allopurinol with febuxostat 80, 120 and 240 mg for achieving the target serum urate.
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CCT including 100 participants with gout (as per ARA criteria) that compared allopurinol 300 mg daily with febuxostat 80 mg daily, over six months and outcomes were assessed at two weeks and then at month four, five and six (final visit).
Allopurinol is approximately 90% absorbed from the gastrointestinal tract.
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The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.
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The duration of gout affecting the participants was reported in all 11 studies, and ranged from a few days to 25 years.
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The second trial with 57 participants, judged to be at low risk of bias, compared the initiation of allopurinol 300 mg during an acute attack of gout versus placebo for 10 days followed by allopurinol 300 mg daily ().
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An increase in the frequency of skin rash has been reported among patients receiving ampicillin or amoxicillin concurrently with Allopurinol compared to patients who are not receiving both drugs.